Primary hyperlipidemia (type IIa including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (type IIb) as an adjunct to diet & reduce elevated total-cholesterol, LDL-cholesterol, Apo B, non HDL-cholesterol & triglycerides levels & to increase HDL-cholesterol. HoFH. Reduce the risk of atherosclerosis by lowering total cholesterol levels & LDL cholesterol levels; risk of CV disease. Primary dysbetalipoproteinemia (type III).
Individualized dosage. May be given at any time of the day. AdultPrimary hyperlipidemia (including heterozygous familial hypercholesterolaemia), mixed dyslipidaemia, dysbetalipoproteinaemia, & HoFH Initially 5 mg once daily. Maintenance dose: 20 mg once daily. Max: 40 mg once daily. Heterozygous familial hypercholesterolaemiaElderly >70 yr 10 mg once daily. Childn 10-17 yr 5 mg once daily. Max: 20 mg once daily. Mild & moderate renal impairment 10-20 mg once daily. Asian patients Initially 5 mg. Patients known to have myopathy 5 mg once daily.
Active liver disease including unexplained, persistent elevations of hepatic transaminase levels. Women of child bearing potential. Pregnancy & lactation.
Hypersensitivity. Patients w/ liver disease; severe kidney problems; has repeated or unexplained muscle aches or pains. Do not administer high dose in patients w/ moderate kidney problems; problems in thyroid gland; have repeated or unexplained muscle aches or pains, a personal or family history of muscle problems, or a previous history of muscle problems when taking other cholesterol-lowering medicines. Patients who have problems in thyroid gland. Concomitant use w/ fibrates & medicines for HIV infection. Excessive alcohol consumption. Asian patients. Pregnancy & lactation. Not recommended for childn <10 yr.
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